Bahariya Oasis (350 km southwest of Cairo) is the most visited and the most connected. Its market town, Bawiti, has a full range of accommodation and is the usual launch point for White Desert trips from Cairo. It is also the site of the Valley of the Golden Mummies — a necropolis of some 230 Greco-Roman mummies discovered in 1996, some gilded, many now in the local museum. The oasis sits in a bowl below the Black Desert plateau; date palms and warm springs characterise its floor.
Farafra Oasis (180 km south of Bahariya) is the smallest of the five and the quietest — a cluster of white-washed mud-brick houses, a cold spring on the edge of town and a handful of small guesthouses. It exists as a destination almost entirely because of the White Desert on its northern boundary. Qasr El Farafra, the old fortified part of town, is worth an hour's wander. Local tomatoes and carrot juice are, inexplicably, exceptional.
Dakhla Oasis (300 km southeast of Farafra) is the most historically layered of the chain. Al-Qasr, its medieval mud-brick village, is partly preserved and occupies the same street layout it had under Ottoman and Islamic rule. Deir El Hagar is a Roman temple of Thoth. The oasis also has hot springs at Mut, the main town, and a small museum. It feels less touristic than Bahariya and more genuinely lived-in than Farafra.
Kharga Oasis (200 km east of Dakhla) is the largest and most urban of the five — essentially a regional government town with a population of over 60,000. It has the best Pharaonic remains in the chain: the Temple of Hibis, one of the best-preserved temples in Egypt from the Late Period, and the Necropolis of Bagawat, a fourth-century Christian cemetery of mud-brick chapels. Kharga is a useful exit point if you're looping back to the Nile valley via Luxor.
Siwa Oasis stands entirely apart from this chain — not connected by paved road to the other four until the Siwa–Bahariya desert track was improved — isolated to the northwest, closer to Libya than to Cairo, and culturally Berber rather than Egyptian Arab. It is reached from the Mediterranean coast at Marsa Matrouh, not from the main oasis road. This separation is part of its character; it has preserved its own language (Siwi), its own architecture (kershef), and a pace that the more accessible oases have partly lost.